importin beta การใช้

• The protein encoded by this gene is a member of the importin beta family.
• Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore.
• Importin beta can also carry proteins into the nucleus without the aid of the importin alpha adapter protein.
• Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex.
• The name " HEAT " is an acronym for four proteins in which this repeat structure is found : importin beta contains 19 HEAT repeats.
• Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex.